Larry Brilliant
Larry Brilliant has been called a polymath, a visionary, and a man who has been at the right time and the right place for some of the most important events in our lifetime. Named one of Time’s 100 Most Influential People, he is a philanthropist, futurist, technologist, and renowned epidemiologist who led the World Health Organization’s Smallpox Eradication Program that saved two million lives. He is the inaugural Executive Director of Google.org, the charitable arm of Google, and the first CEO of Skoll Global Threats Fund. His life and career are filled with unexpected experiences and supported by a remarkable cast of characters. The stories of these experiences coalesce into moving talks that inspire audiences to adopt an optimistic outlook despite the many reasons not to, and to be the change they wish to see in the world.
As the CEO of Evity.ai, a company at the intersection of epidemiology, healthspan, and AI, his goal is to rewrite the future of healthy living through technology, reducing the number of years we spend in “sickspan,” the years at the end of life when health care costs are highest and suffering is most acute. Uniting longevity research, medical science, and clinical reasoning with the power of AI, Evity’s platform for healthcare systems can deliver real-time personalized guidance. The result is a system that’s trusted by clinicians and easy for patients to use.
Early in his career, Brilliant lived in a Himalayan monastery in India for nearly a decade. His teacher there advised him to use his medical degree for service. He eventually rose to become leader of the World Health Organization Smallpox Eradication Program in India and South Asia, becoming a pivotal figure in a historic campaign that achieved the first and only eradication of one of the oldest and deadliest diseases known to humanity. His memoir Sometimes Brilliant is a riveting account of the heroic efforts of the extraordinary people involved in the eradication of smallpox in India.
Brilliant’s transforming experience in eradicating smallpox sparked his journey as a self-professed social change addict. Alongside his wife, he co-founded the Seva Foundation, an NGO that has helped restore eyesight to over 30 million people in two dozen countries. In 2005, he founded and is currently the CEO of Pandefense Advisory, an interdisciplinary network of experts advising private, public, philanthropic, and nonprofit organizations on pandemic awareness, prevention, and response.
An MD and MPH who is board certified in preventive medicine and public health, Brilliant was an associate professor of epidemiology at the University of Michigan, chairman of the National Bio-surveillance Advisory Committee, and a member of the World Economic Forum’s agenda council on catastrophic risk. He is a member of the DOC 2026 Faculty, joining a community of exceptional minds dedicated to transforming health. He was also a science advisor on Steven Soderbergh’s Contagion, produced the Open Your Eyes and The Final Inch documentaries, and was featured in the documentaries Unseen Enemy, Saint Misbehavin’, Ram Dass Fierce Grace, and Medicine Ball Caravan.
He has been named UC Berkeley’s International Public Health Hero, and is the recipient of the TED Prize, the UCLA Medal, and several honorary doctorate degrees. A highly sought after speaker, he has lectured at the White House, NIH, the Pentagon, the Royal Society and Oxford. He has delivered inspiring commencement speeches at many universities including Harvard, University of Michigan, and UCSF Medical School. In the corporate space, he has given over 100 presentations to top companies and events including Salesforce’s Dreamforce, Davos, Aspen Ideas, Google, and Cisco.
For more information, please visit larrybrilliant.com.
Larry Brilliant has been called a polymath, a visionary, and a man who has been at the right time and the right place for some of the most important events in our lifetime. Named one of Time’s 100 Most Influential People, he is a philanthropist, futurist, technologist, and renowned epidemiologist who led the World Health Organization’s Smallpox Eradication Program that saved two million lives. He is the inaugural Executive Director of Google.org, the charitable arm of Google, and the first CEO of Skoll Global Threats Fund. His life and career are filled with unexpected experiences and supported by a remarkable cast of characters. The stories of these experiences coalesce into moving talks that inspire audiences to adopt an optimistic outlook despite the many reasons not to, and to be the change they wish to see in the world.
As the CEO of Evity.ai, a company at the intersection of epidemiology, healthspan, and AI, his goal is to rewrite the future of healthy living through technology, reducing the number of years we spend in “sickspan,” the years at the end of life when health care costs are highest and suffering is most acute. Uniting longevity research, medical science, and clinical reasoning with the power of AI, Evity’s platform for healthcare systems can deliver real-time personalized guidance. The result is a system that’s trusted by clinicians and easy for patients to use.
Early in his career, Brilliant lived in a Himalayan monastery in India for nearly a decade. His teacher there advised him to use his medical degree for service. He eventually rose to become leader of the World Health Organization Smallpox Eradication Program in India and South Asia, becoming a pivotal figure in a historic campaign that achieved the first and only eradication of one of the oldest and deadliest diseases known to humanity. His memoir Sometimes Brilliant is a riveting account of the heroic efforts of the extraordinary people involved in the eradication of smallpox in India.
Brilliant’s transforming experience in eradicating smallpox sparked his journey as a self-professed social change addict. Alongside his wife, he co-founded the Seva Foundation, an NGO that has helped restore eyesight to over 30 million people in two dozen countries. In 2005, he founded and is currently the CEO of Pandefense Advisory, an interdisciplinary network of experts advising private, public, philanthropic, and nonprofit organizations on pandemic awareness, prevention, and response.
An MD and MPH who is board certified in preventive medicine and public health, Brilliant was an associate professor of epidemiology at the University of Michigan, chairman of the National Bio-surveillance Advisory Committee, and a member of the World Economic Forum’s agenda council on catastrophic risk. He is a member of the DOC 2026 Faculty, joining a community of exceptional minds dedicated to transforming health. He was also a science advisor on Steven Soderbergh’s Contagion, produced the Open Your Eyes and The Final Inch documentaries, and was featured in the documentaries Unseen Enemy, Saint Misbehavin’, Ram Dass Fierce Grace, and Medicine Ball Caravan.
He has been named UC Berkeley’s International Public Health Hero, and is the recipient of the TED Prize, the UCLA Medal, and several honorary doctorate degrees. A highly sought after speaker, he has lectured at the White House, NIH, the Pentagon, the Royal Society and Oxford. He has delivered inspiring commencement speeches at many universities including Harvard, University of Michigan, and UCSF Medical School. In the corporate space, he has given over 100 presentations to top companies and events including Salesforce’s Dreamforce, Davos, Aspen Ideas, Google, and Cisco.
For more information, please visit larrybrilliant.com.
AI for Health
For fifty years, Larry Brilliant has chased a single question: what does it take to end suffering at scale? As a WHO Medical Officer in the 1970s, he was part of the team that eradicated smallpox from South Asia, an experience which taught him that when knowledge is organized for the benefit of humanity, health can change at a global scale. Now the CEO of Evity Technologies, a company at the intersection of epidemiology, healthspan, and AI, he’s tackling a new epidemic: the 14–15 years the average American spends in “sickspan”, years of chronic disease near the end of life, where we spend 90% of our health care dollars and endure 90% of our suffering. In this engrossing talk, Brilliant discusses his company’s AI-powered prevention intelligence platform and its transformative implications for clinicians, patients, and the entire health-care system.
The Case for Optimism
In his work as a physician and epidemiologist, Larry Brilliant has witnessed some of the greatest existential threats to humanity, but he remains optimistic. Rather than focusing on all the hurt and harm in the world, he instead turns his sights to those beacons of hope working to make the world a better place. There are many reasons to be pessimistic about the future but with every act of goodwill comes an even more convincing reason to be optimistic. In this talk, Larry shares the incredible stories of ordinary people who accomplished extraordinary feats that changed the world—stories that keep his spirits high in the face of hardship. A call to action to everyone in the audience, this inspirational talk will leave audiences on a high note, motivated to fulfill their duty to make the world a better place.
Expanding the Boundaries of Philanthropy
What comes to mind when you hear the word philanthropy? Most of us think of hefty checks to worthy causes. But such thinking limits the act of philanthropy to the wealthy when, in fact, we should all commit to philanthropic efforts. Philanthropy isn’t always money, and money isn’t always the best solution. A global philanthropist who has founded and advised many charitable organizations in his career, Larry Brilliant asks you to think creatively about the ways you can give back. How can you serve your community with your time, your expertise, your access to things out of reach? We all have something to offer. For every aspect of our lives that we take for granted, there is someone for whom those very things could be life changing. Embracing philanthropy as a universal endeavor, regardless of financial means, empowers us to share our unique gifts and make meaningful impacts in the lives of others.
- Sometimes Brilliant: The Impossible Adventure of a Spiritual Seeker and Visionary Physician Who Helped Conquer the Worst Disease in History (HarperOne, 2017)
- 2014 UCLA Medal, University of California, Los Angeles
- 2006 TED Prize
- 2004 International Public Health Hero Award, University of California, Berkeley
What a welcome relief to see this story of someone with soul and a great healing spirit coming out of Silicon Valley, to actually – literally – help in saving the world.
Larry Brilliant’s story [is] …. a reminder that real progress in improving the lives of other human beings is within our grasp.
- WATCH: The State of AI in Precision Health: Larry Brilliant, Usama Fayyad, The Institute for Experiential AI
- WATCH: Ahead of the Curve: Larry Brilliant, University of Michigan School of Public Health
- READ: This doctor helped eradicate smallpox. Now he wants to use AI to help health care workers make better decisions about patient care, Northeastern Global News
- READ: From Smallpox to AI: Key Lessons from Larry Brilliant and Usama Fayyad’s Discussion at The State of AI in Precision Health, The Institute for Experiential AI
- Speaking from experience on what makes a global killer, The Harvard Review
- The Doctor Who Helped Defeat Smallpox Explains What’s Coming, WIRED
- LISTEN: Sometimes Brilliant with Larry Brilliant, Inside Personal Growth









